Abstract
Introduction: Rapidly dissolving oral films (RDOFs) and “mouth-melting” or “dissolve-in-mouth” (DIM) tablets represent novel pharmaceutical delivery systems engineered to dissolve or disintegrate when coming into contact with saliva. They present a convenient and hydration-independent approach to administering medications, proving particularly advantageous for individuals such as children and those facing difficulties with conventional tablet consumption. These pharmaceutical forms are applicable to a wide range of drugs and are manufactured through diverse methodologies, including patented technologies like Zydis and OraSolv. They offer benefits such as enhanced patient adherence, swift onset of drug action, increased drug absorption, and prolonged stability.
Discussion: Fast-dissolving oral films (FDOFs) are slender strips designed to dissolve rapidly, providing benefits such as swift drug onset and user-friendliness, particularly for pediatric and geriatric populations. While they do have certain constraints, FDOFs excel in terms of dissolution rates and bioavailability when compared to traditional tablets, positioning them as a promising choice for managing conditions like allergic rhinitis.
Conclusion:
It has been determined that fast-dissolving oral films (FDOFs) provide a patient- friendly, rapid drug delivery method with improved bioavailability, making them well- suited for individuals facing difficulties with conventional tablets. Despite encountering formulation complexities, FDOFs exhibit superior performance in comparative research, ensuring swifter and more predictable drug release, resulting in quicker therapeutic outcomes. They hold substantial potential for addressing a wide range of medical conditions, contributing to better patient adherence and expedited drug delivery, and are poised to drive further innovations in healthcare.
KEYWORDS
Antihistamine, Mouth dissolving films, Allergy, Solvent Casting, Dissolution.
Rizwan Ahmedhusain Bhaijamal1*, Machhi Yashkumar Virabhai2, Maisuriya Aakashkumar B3, Sonu Kachhiya M4
1,2,3,4Genezen Institute of Pharmacy Delol, Kalol-389310, Gujarat, India